I still use my 3G Nano everyday, mainly to help preserve my iPhone's battery life if I'm gonna be out an about all day long and unable to use my car or wall charger. I've noticed too that sometimes the iPhone iPod's playback gets choppy if you're using a resource intensive App at the same time, so I stick with a dedicated music player.
I also use the Nano for running (Nike+); even if the iPhone supported Nike+ there's no way I'd use it, it's just too big and heavy compared to a Nano.
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