Don't us AV either. If I had to run Windows as a working OS in VM or Bootcamp, I'd run AV inside the Windows install. I just use Win to test with, so I don't even bother with that (don't get email in it, don't go to untrusted sites).
Also, if you work to-and-from a lot of PCs, you might consider AV only as a way to help PC users by removing viruses from attachments you receive and forward on from/to infect PCs.
All in all, however, the only real defense is behavior.
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